Key Points
• Cutaneous xanthomas are due to an accumulation of lipid, primarily within dermal macrophages (foam cells), and they have a characteristic yellow-orange hue.
• Four major types of xanthomas: eruptive, tuberous, tendinous, and plane.
• They may be a sign of hyperlipidemia, either primary or secondary, or an underlying monoclonal gammopathy.
• The type of xanthoma and its anatomic location are clues to the specific lipid abnormality or associated disorder (Table 77.1; Figs. 77.1 and 77.2).
• DDx depends on the type of xanthoma (Table 77.2).
• In general, Rx is focused on correcting any underlying hyperlipidemia.

Table 77.1

Fig 77.1

Fig 77.2

Table 77.2

Xanthomas Associated with Hyperlipidemia
Eruptive Xanthomas
• Yellow-pink papules, 1–5 mm in diameter.
• May be widespread, but favor the extensor surfaces of the extremities and buttocks (Figs. 77.3 and 77.4).
• An inflammatory halo, tenderness, and/or pruritus may be present.
• Associated with hypertriglyceridemia (often >3000–4000 mg/dl) (see Fig. 77.2).
• Seen in the setting of type I, IV, or V hyperlipidemia and most commonly when associated diabetes mellitus is under poor control.
• Lesions often resolve within weeks of aggressive Rx: insulin; triglyceride-lowering agents, e.g. fenofibrate.

Fig 77.3

Fig 77.4

Tuberous/Tuberoeruptive Xanthomas
• Pink-yellow to yellow-brown papules (tuberoeruptive) or nodules (tuberous) on extensor surfaces, especially the elbows and knees (Figs. 77.5 and 77.6); tuberous xanthomas can be >3 cm in diameter.
• Associated with hypercholesterolemia (type II or III hyperlipidemia).
• May be slow to regress with cholesterollowering agents (e.g. ‘statins’).

Fig 77.5

Fig 77.6

Tendinous Xanthomas
• Firm, smooth, skin-colored nodules due to lipid deposits within the Achilles tendons and the extensor tendons of the hands, knees, and/or elbows (Figs. 77.7 and 77.8).
• Can serve as an early clue to the presence of type II hyperlipidemia.
• Rarely form as a consequence of accumulation of cholestanol (cerebrotendinous xanthomatosis) or plant sterols (β-sitosterolemia).

Fig 77.7

Fig 77.8

Plane Xanthomas and Xanthelasma
• Yellow to orange macules and patches or thin papules and plaques.
• Of the different types of xanthomas, xanthelasma is the most common; however, hyperlipidemia is detected in only 50% of patients.
• Site:
– Intertriginous – antecubital fossae, finger web spaces, and palmar creases (Figs. 77.9 and 77.10).
– Eyelids (xanthelasma), especially the medial aspect of the upper eyelid (Fig. 77.11).
• Intertriginous plane xanthomas can be seen in primary hyperlipidemia (type II or III) as well as secondary hyperlipidemia (e.g. biliary atresia, primary biliary cirrhosis).
• Rx of xanthelasma: destructive methods (e.g. trichloroacetic acid application, laser ablation), surgical excision.
Laboratory evaluation for suspected hyperlipidemia is outlined in Table 77.3.

Fig 77.9

Fig 77.10

Fig 77.11

Normolipemic Xanthomas
Plane Xanthomas Associated with Monoclonal Gammopathy
• In contrast to plane xanthomas due to hyperlipidemia, these yellow-orange patches and thin plaques are usually larger in size and have a more extensive distribution pattern; the latter often includes the trunk (Fig. 77.12).
• In addition to the trunk, lesions may be seen on the neck, in flexural folds, and in the periorbital region.
• The monoclonal gammopathy is most commonly due to a plasma cell dyscrasia, and occasionally due to a lymphoproliferative disorder.

Fig 77.12

Verruciform Xanthoma
• Asymptomatic verrucous plaque, 1 to 2 cm in diameter (Fig. 77.13).
• Oral mucosa or anogenital region.
• May be seen in association with lymphedema, epidermolysis bullosa, and CHILD (congenital hemidysplasia with ichthyosiform erythroderma and limb defects) syndrome.

Fig 77.13